Age related macular degeneration
Age related macular degeneration (AMD) is one of the commonest causes of vision loss in those over 50 in Australia. It results in damage to the macula, the very centre of the retina. The retina is the “film of the camera”. It converts the light that you see into electrical signals to the brain. The macula is the area that gives us our reading vision, colour vision and driving vision.
What are the symptoms of AMD
Damage to the macula results in blurred vision and visual distortion. It causes reduced central vision which impairs reading, watching TV and driving. Distortion results in straight lines looking bent or wavy. Colour vision may also be impaired.
What is the difference between Wet AMD and Dry AMD
Dry AMD starts with the build up of drusen or “age spots” in the retina. Vision is usually good or only slightly reduced at this stage, and patients can remain at this stage without progression for decades. Most of these patients with mild dry AMD can continue to read and drive, although it may not be as easy as it was when they were younger. Some patients, but not all, progress to a more advanced stage of Dry AMD called geographic atrophy. This can result in severe loss of central vision and loss of the ability to read and drive. Unfortunately there is no treatment for dry AMD although there is a lot of ongoing research overseas.
Wet AMD is very treatable and treatment is urgent as the sooner the treatment is commenced, the better. Wet AMD occurs when abnormal new blood vessels grow into the retina and start leaking fluid. This causes the retina to swell and the longer it is swollen the more the retinal fibres deteriorate. If the abnormal blood vessels bleed into the retina, this can do severe damage, which is often permanent.
Who gets AMD?
AMD occurs most commonly in otherwise healthy elderly adults usually 60 years of age or older. It is much more common in those who were heavy smokers and in those with high blood pressure and other cardiovascular risk factors. It does occur though in many people with no risk factors at all other than their age
What causes it?
The cause of AMD is not known and it usually multifactorial. While there are some genetic factors there it usually does not strongly run in families. It is definitely not due to how you use your eyes, and is not due to eyestrain, too much reading or computer work etc.
How is the diagnosis made?
AMD is diagnosed with a combination of clinical examination, colour retinal photographs and special scans. An OCT scan takes high resolution images at high magnification to see what layer of the retina is affected by the fluid. A fluorescein angiogram is a very commonly performed dye test where a nurse injects some special dye into a vein in your arm, and then photographs the dye passing through the retinal blood vessels to see where the fluid is leaking from.
What is the visual prognosis?
The prognosis for most patients with AMD with modern treatment is relatively good if treatment is commenced early before too much damage is done. Untreated, the prognosis is terrible, with the majority of untreated patients progressing to legal blindness in one or both eyes. This is not a condition which will ever make you completely blind. In severe cases though it can result in severe loss of central vision which can impair the ability to read and drive with that eye. Your peripheral vision will very rarely be involved and even severely affected patients retain peripheral vision sufficient to see where they are walking and remain relatively independent.
Recurrences are common, and monitoring and treatment may need to continue for life.
Treatment
There is no cure for wet AMD but modern medical treatment has resulted in dramatically improved outcomes, since intravitreal injections became available in Australia in 2006-7.
For those who require treatment, there are three options:
1. Intravitreal injections of medicine (Avastin, Eylea, Lucentis)
2. Photodynamic Therapy with Visudyne
3. Thermal Laser
Intravitreal injections (Avastin, Eylea or Lucentis) Intravitreal injections have rapidly become the most common and most successful treatment for retinal swelling due to retinal vascular disorders such as AMD and diabetic retinopathy.
These works by reducing swelling in the retina. It turns off the leakage of fluid into the retina, and works in more than 90% of people with macular degeneration. The effect on the abnormal blood vessels is dramatic, like putting weed killer on weeds, they rapidly shrink away. Each year there are more than half a million intravitreal eye injections performed in the USA. See below for more information on intravitreal injection treatment.
Photodynamic Therapy (PDT) with Verteporfin (Visudyne) involves an infusion of special dye (Verteporfin / Visudyne) followed by a special “cold” laser which activates the dye in the retina.
For those cases not suitable for thermal laser, this is a very good alternative. It will result in resolution of the fluid in approximately two thirds of patients. Unfortunately approximately one third of patients do not respond and the fluid persists. In some of these cases a second treatment can result in resolution of the fluid. There is a small, 1-4% chance that the PDT can make the vision worse, and this would be permanent. The significant disadvantage of PDT is that it is not covered by medicare and to purchase the Visudyne dye from the drug company costs $2000.
ƒThermal Laser
Only a very small percentage of cases are suitable for laser. Laser is only possible in those uncommon cases where the AMD begins a long distance away from the macula and the centre of the macula is unaffected. The success rate for laser depends on how far away the leak site is from the centre of the macula. If the leak is a long way away from the centre of the macula, laser treatment has a very high chance of success.
If the leak is very close to the centre, laser has a risk of resulting in a permanent dark spot in the vision.
If the leak is directly underneath the centre, laser is not possible as it would make the vision worse.
Intravitreal injection treatment for AMD
Which medicine is best?
There are 3 options currently available in Australia, Avastin, Lucentis and Eylea. At present all three are thought by most retina specialists to be equivalent and this has been demonstrated in many large trials in the United States. More trials are currently underway to help distinguish between the three.
How are the treatments given?
The treatments for wet AMD are administered as an injection into the eye. A tiny needle much smaller than a blood test needle is used. A lot of strong anaesthetic eye drops are used, and some people do not feel the needle at all. Just like a blood test, you do often feel a small, momentary sharp sensation, but only for a split second. A lot of antiseptic drops are used to prevent infection, and these eyedrops do sting and irritate the eye, like salt water at the beach. Some people find the antiseptic drops very irritating and the eye can be very red, watery & irritated for 24-72 hours. Some people feel only minimal irritation for a few hours.
********
IT IS EXTREMELY IMPORTANT NOT TO RUB THE EYE AFTER THE PROCEDURE. THIS CAN CAUSE SEVERE PAIN.
********
IT IS ALSO EXTREMELY IMPORTANT TO TRY TO KEEP THE EYE CLOSED AS MUCH AS POSSIBLE FOR A FEW HOURS AFTERWARDS TO PREVENT THE CORNEA DRYING OUT.
********
How long does the injection last?
It is important to understand that the injection is not a cure for a retinal vein occlusion. The Avastin lasts in the eye for 4-6 weeks, and once it wears off the swelling will often return and re-treatment is required.
How long do I need treatment for?
The aim is to keep the retina dry and the swelling down until the swelling stops recurring. This means treatment every 4 - 8 weeks until you’re the blood vessels are completely inactive. In some people this occurs as early as 3 months. In others it can take longer than 12 months. In some people, especially those who are older or who had more severe disease at presentation, the blood vessels continue to recur and they face the prospect of continuing treatment indefinitely or until newer longer lasting treatments become available. Fortunately there are newer treatments in development that can last many months and new “slow release” technologies may allow treatment only once per year.
What are the risks of treatment?
There is a small risk of infection in the eye, with any injection procedure. This risk is around 1 in 1000. It is usually treatable if detected early. Rarely a severe infection which does not respond to antibiotics can result in blindness. It is therefore extremely important to contact us if you experience severe pain or vision deterioration.
What happens after the injection?
Hopefully over the weeks after the injection, you will notice the vision stops deteriorating and in many cases it actually improves. The vision usually improves a little further after each treatment, over the first three months. With regular follow-up, the visual prognosis for AMD is much better than it was even five years ago. A follow-up appointment will be made in four weeks to check your progress.
Age related macular degeneration (AMD) is one of the commonest causes of vision loss in those over 50 in Australia. It results in damage to the macula, the very centre of the retina. The retina is the “film of the camera”. It converts the light that you see into electrical signals to the brain. The macula is the area that gives us our reading vision, colour vision and driving vision.
What are the symptoms of AMD
Damage to the macula results in blurred vision and visual distortion. It causes reduced central vision which impairs reading, watching TV and driving. Distortion results in straight lines looking bent or wavy. Colour vision may also be impaired.
What is the difference between Wet AMD and Dry AMD
Dry AMD starts with the build up of drusen or “age spots” in the retina. Vision is usually good or only slightly reduced at this stage, and patients can remain at this stage without progression for decades. Most of these patients with mild dry AMD can continue to read and drive, although it may not be as easy as it was when they were younger. Some patients, but not all, progress to a more advanced stage of Dry AMD called geographic atrophy. This can result in severe loss of central vision and loss of the ability to read and drive. Unfortunately there is no treatment for dry AMD although there is a lot of ongoing research overseas.
Wet AMD is very treatable and treatment is urgent as the sooner the treatment is commenced, the better. Wet AMD occurs when abnormal new blood vessels grow into the retina and start leaking fluid. This causes the retina to swell and the longer it is swollen the more the retinal fibres deteriorate. If the abnormal blood vessels bleed into the retina, this can do severe damage, which is often permanent.
Who gets AMD?
AMD occurs most commonly in otherwise healthy elderly adults usually 60 years of age or older. It is much more common in those who were heavy smokers and in those with high blood pressure and other cardiovascular risk factors. It does occur though in many people with no risk factors at all other than their age
What causes it?
The cause of AMD is not known and it usually multifactorial. While there are some genetic factors there it usually does not strongly run in families. It is definitely not due to how you use your eyes, and is not due to eyestrain, too much reading or computer work etc.
How is the diagnosis made?
AMD is diagnosed with a combination of clinical examination, colour retinal photographs and special scans. An OCT scan takes high resolution images at high magnification to see what layer of the retina is affected by the fluid. A fluorescein angiogram is a very commonly performed dye test where a nurse injects some special dye into a vein in your arm, and then photographs the dye passing through the retinal blood vessels to see where the fluid is leaking from.
What is the visual prognosis?
The prognosis for most patients with AMD with modern treatment is relatively good if treatment is commenced early before too much damage is done. Untreated, the prognosis is terrible, with the majority of untreated patients progressing to legal blindness in one or both eyes. This is not a condition which will ever make you completely blind. In severe cases though it can result in severe loss of central vision which can impair the ability to read and drive with that eye. Your peripheral vision will very rarely be involved and even severely affected patients retain peripheral vision sufficient to see where they are walking and remain relatively independent.
Recurrences are common, and monitoring and treatment may need to continue for life.
Treatment
There is no cure for wet AMD but modern medical treatment has resulted in dramatically improved outcomes, since intravitreal injections became available in Australia in 2006-7.
For those who require treatment, there are three options:
1. Intravitreal injections of medicine (Avastin, Eylea, Lucentis)
2. Photodynamic Therapy with Visudyne
3. Thermal Laser
Intravitreal injections (Avastin, Eylea or Lucentis) Intravitreal injections have rapidly become the most common and most successful treatment for retinal swelling due to retinal vascular disorders such as AMD and diabetic retinopathy.
These works by reducing swelling in the retina. It turns off the leakage of fluid into the retina, and works in more than 90% of people with macular degeneration. The effect on the abnormal blood vessels is dramatic, like putting weed killer on weeds, they rapidly shrink away. Each year there are more than half a million intravitreal eye injections performed in the USA. See below for more information on intravitreal injection treatment.
Photodynamic Therapy (PDT) with Verteporfin (Visudyne) involves an infusion of special dye (Verteporfin / Visudyne) followed by a special “cold” laser which activates the dye in the retina.
For those cases not suitable for thermal laser, this is a very good alternative. It will result in resolution of the fluid in approximately two thirds of patients. Unfortunately approximately one third of patients do not respond and the fluid persists. In some of these cases a second treatment can result in resolution of the fluid. There is a small, 1-4% chance that the PDT can make the vision worse, and this would be permanent. The significant disadvantage of PDT is that it is not covered by medicare and to purchase the Visudyne dye from the drug company costs $2000.
ƒThermal Laser
Only a very small percentage of cases are suitable for laser. Laser is only possible in those uncommon cases where the AMD begins a long distance away from the macula and the centre of the macula is unaffected. The success rate for laser depends on how far away the leak site is from the centre of the macula. If the leak is a long way away from the centre of the macula, laser treatment has a very high chance of success.
If the leak is very close to the centre, laser has a risk of resulting in a permanent dark spot in the vision.
If the leak is directly underneath the centre, laser is not possible as it would make the vision worse.
Intravitreal injection treatment for AMD
Which medicine is best?
There are 3 options currently available in Australia, Avastin, Lucentis and Eylea. At present all three are thought by most retina specialists to be equivalent and this has been demonstrated in many large trials in the United States. More trials are currently underway to help distinguish between the three.
How are the treatments given?
The treatments for wet AMD are administered as an injection into the eye. A tiny needle much smaller than a blood test needle is used. A lot of strong anaesthetic eye drops are used, and some people do not feel the needle at all. Just like a blood test, you do often feel a small, momentary sharp sensation, but only for a split second. A lot of antiseptic drops are used to prevent infection, and these eyedrops do sting and irritate the eye, like salt water at the beach. Some people find the antiseptic drops very irritating and the eye can be very red, watery & irritated for 24-72 hours. Some people feel only minimal irritation for a few hours.
********
IT IS EXTREMELY IMPORTANT NOT TO RUB THE EYE AFTER THE PROCEDURE. THIS CAN CAUSE SEVERE PAIN.
********
IT IS ALSO EXTREMELY IMPORTANT TO TRY TO KEEP THE EYE CLOSED AS MUCH AS POSSIBLE FOR A FEW HOURS AFTERWARDS TO PREVENT THE CORNEA DRYING OUT.
********
How long does the injection last?
It is important to understand that the injection is not a cure for a retinal vein occlusion. The Avastin lasts in the eye for 4-6 weeks, and once it wears off the swelling will often return and re-treatment is required.
How long do I need treatment for?
The aim is to keep the retina dry and the swelling down until the swelling stops recurring. This means treatment every 4 - 8 weeks until you’re the blood vessels are completely inactive. In some people this occurs as early as 3 months. In others it can take longer than 12 months. In some people, especially those who are older or who had more severe disease at presentation, the blood vessels continue to recur and they face the prospect of continuing treatment indefinitely or until newer longer lasting treatments become available. Fortunately there are newer treatments in development that can last many months and new “slow release” technologies may allow treatment only once per year.
What are the risks of treatment?
There is a small risk of infection in the eye, with any injection procedure. This risk is around 1 in 1000. It is usually treatable if detected early. Rarely a severe infection which does not respond to antibiotics can result in blindness. It is therefore extremely important to contact us if you experience severe pain or vision deterioration.
What happens after the injection?
Hopefully over the weeks after the injection, you will notice the vision stops deteriorating and in many cases it actually improves. The vision usually improves a little further after each treatment, over the first three months. With regular follow-up, the visual prognosis for AMD is much better than it was even five years ago. A follow-up appointment will be made in four weeks to check your progress.